Cameron W Evans, PhD

We are investigating the role of unusual DNA and RNA structures (G-quadruplexes and i-motifs) in gene regulation, and how these structures can be harnessed for therapy.

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We are examining metastasis and drug resistance in breast cancer using models of epithelial–mesenchymal transition in cells. Using the latest single-cell sequencing techniques, we are investigating how cancer cells change and acquire invasive properties. Our work may help uncover new ways to improve the response to anticancer therapies and prevent tumour recurrence in breast cancer.

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Gene therapies help to reprogramme cells, correcting errors in gene expression that cause disease. We are designing macromolecules that help to introduce nucleic acids, proteins, and gene editing platforms into living cell cultures. We have developed this technology to allow barcoding and multiplexing of single-cell sequencing samples. Our platform could lead to the translation of novel gene therapies as well as tools for scientists to investigate the roles of specific genes.

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Developing methods to amplify signals in cells and detect individual molecules can help us pinpoint the location of therapeutic molecules and track their journey through cells. We are also using expansion microscopy, a technique in which tissue samples are embedded in a swellable hydrogel and expanded in size before looking under the microscope. These experiments will help us understand the trafficking and distribution of the latest RNA-based therapeutics.

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I am collaborating with research groups in Perth to help them encapsulate therapeutic oligos in lipid nanoparticles for successful delivery of therapies against liver cancer and other diseases. Encapsulation in lipid nanoparticles helps to protect the oligo against degradation, and ensures effective delivery to the site of action.

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I have developed hydrogels for delivery of immunotherapies in sarcoma, which are now being tested in domestic dogs that have had tumours removed by a veterinary oncologist. The gels help to prevent recurrence by activating the immune system to help eradicate remaining cancer cells. We are also developing hydrogels to deliver a sustained dose of drug to the eye to combat retinitis pigmentosa—a genetic, blinding retinal disorder.

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